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romi1011 · 04-10-2006, 12:54 AM

can anyone answer these questions? please

1. The half life of a drug is 9 days. a single 0.5 mg dose of the drug yields an [AUC] value of 408 ng h/ml. in nanograms per ml, what plasma level will resuly at steady state if this product is given once daily and is 77% bioavailable?

a. 5
b. 13
c. 17
d. 23

Ans: Css=AUC/T = 408/24 = 17
how will the value of T be 24?

2. A solution initially contains methyl acetate(0.01 M) and NaOH (0.01M). the solution is unbuffered and both reacting species are consumed. if the rate constatnt for this reaction at 25 degrees C is 1.082 litres/(mole.min), hoe many minutes will it take for the concentration of methly acetate to fall to 0.0090 M?

a. 92.4
b. 33.6
c. 10.3
d. 0.10

1/c-1/c0 = kt

Six hours after 500 mg of a drug is administered by IV injection, a patient's plasma concentration Is 10 microg/ ml .

If T 1/2 = 4 h
( MEC ) = 2 micorg/ ml

How many hours after the first dose should a second dose be administered ?

The radioactive decay of radium has a rate constant of 0.000422 per year. How many years will it take for 20% of the radium initially present to degrade? (The amount initially present can be specified as 100%.)

A. 230
B. 529
C. 1000
D. 3815
The answer is B (529).

04-10-2006, 12:54 AM	#1 (permalink)
romi1011 Trying to make mom and pop proud Join Date: Jun 2005 Posts: 25	can any one slove this calculation can anyone answer these questions? please 1. The half life of a drug is 9 days. a single 0.5 mg dose of the drug yields an [AUC] value of 408 ng h/ml. in nanograms per ml, what plasma level will resuly at steady state if this product is given once daily and is 77% bioavailable? a. 5 b. 13 c. 17 d. 23 Ans: Css=AUC/T = 408/24 = 17 how will the value of T be 24? 2. A solution initially contains methyl acetate(0.01 M) and NaOH (0.01M). the solution is unbuffered and both reacting species are consumed. if the rate constatnt for this reaction at 25 degrees C is 1.082 litres/(mole.min), hoe many minutes will it take for the concentration of methly acetate to fall to 0.0090 M? a. 92.4 b. 33.6 c. 10.3 d. 0.10 1/c-1/c0 = kt Six hours after 500 mg of a drug is administered by IV injection, a patient's plasma concentration Is 10 microg/ ml . If T 1/2 = 4 h ( MEC ) = 2 micorg/ ml How many hours after the first dose should a second dose be administered ? The radioactive decay of radium has a rate constant of 0.000422 per year. How many years will it take for 20% of the radium initially present to degrade? (The amount initially present can be specified as 100%.) A. 230 B. 529 C. 1000 D. 3815 The answer is B (529).