Quote:
Originally Posted by LadyJane
Hi Pharmacist!
Thank you for you post, that is a good one.
In my experience I made index carts for inhibitors, inducers and substrates and consult them all the time. For me it's easy to remember this way.
Also I want to mention warfarin which is a substrate of 3A4. It has lots of interactions and we have to be careful with it - monitor INR is a usual response for interaction with this drug.
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Thanks,
Also I'd like to share another information which really surprised me. As you know , CYP2D6 is no less important than CYP3A4. It metabolises so many drugs including TCA 's and some cardiovascular drugs. CYP2D6 is inactive in
6 % of white people which puts millions under the risk of adverse reactions .
Genotyping of CYP2D6 is becoming increasingly important to determine the appropriate dose of TCA to be administered. Important inhibitors of CYP2D6 include SSRI's and Cimitidine and others that I can't remember now.