1)1 quart is 960 cc:1 table spoon is 15 ml.
put the values in you will get C
1)1 tablespoonful of thioridazine solution ( 100mg/cc) is diluted with water up to 1 quart, what is the % of drug in the final solution?
a)1.25%
b)0.005%
c)0.156%
d)2.75%
Answer: c..please explain how to get it?
2)The recommended therapeutic dose for Levaquin I.V is 7mg/kg/day. The drug has elimination half life of 12hrs. Volume of distribution is 1.2l/kg. What would be the plasma concentration of the drug.? Pt wt 170lbs. What would be the initial plasma concentration of drug in mg/ml?
a)10.11 mcg/ml
b)23.12 mcg/ml
c)5.833 mcg/ml
d)33.23 mcg/ml
Answer: c
3)The recommended plasma concentration of cipro is 20 mcg/ml. Elimination half life 6hrs. volume distribution 0.5 l/kg. pt weight 155lbs. what would be the rate of infusion in mg/min/
a) 2.25 mg/min
b)5.60 mg/min
c)1.35mg/min
d)1.1mg/min
Answer :c
Please solve these qs and explain how u solved it.
Thanks.
Hi
the answer for 3rd question is
Rate of infusion=CssxCL
Css=steady state concentration, Cl=clearance
Cl=Vd x Ke
=0.5l/kg, for 155lbs it is 35.23litres,Ke=0.693/t1/2
Ke=0.693/6=0.1155
Cl=35.23x0.1155=4.068litres/hour
we need to calculate dose for doing Css. Vd=Dose/Cp
Vd=35.23=dose/20mcg/ml 20mcg=0.02mg/ml
since Vd is in litres, 0.02x1000=20 mg in litres
Dose=35.23x20=704.6mg
Css=Dose/Vd= 704.6/35.23=20mg/litres
Rate of infusion-=CssxCl=20x4.068litres/hour=81.36mg/hour
as the answer inminutes, you divide by 60 to get 1.35mg/min
Please somebody help with Math:
1)5% w/v solution of phenol is diluted by adding 200ml to 4 liters water. What is the strength of the final product?
2)The concentration of codeine in cough syrup is 65mg/30ml. How many ml of diluent should be added to 120 ml of this syrup to obtain a pediatric dos of 1mg/ml?
3)What is the new strength of a solution prepared by diluting with water , 1 pint of a 1:750 strength solution to i gallon?
A)) A patient has bradyarrythmia. Choose the drug which will not worsen pt condition?
a)verapamil
b)sotalol
c)digoxin
d)amlodipine
e)Diltiazem.
1). 5% => 5g -- 100 ml
? -- 200 ml => we have 10 g in 200 ml, which will be diluted to 4litters
10g in 4000 ml
? g in 100 ml => so the strength of the final solution is 1000/4000= 0.25 => 0.25 %
2). 65mg in 30 ml => we have 260 mg in 120 ml, to obtain a concentration of 1mg/ml we need 260 ml
so we need 140 ml of diluent to add to 120 ml of the syrup.
3). 1 pint of 1/750 will be diluted to 1 gallon ( 8 pints )
1/750/8 = 1/6000
4). D, The only drug in the list that does not lower HR is amlodipine
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