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romi1011 · 04-27-2006, 05:18 PM

Q. Requires thio- containing agents to generate nitric oxide (NO)

nitroglycerin
nitroprusside sodium (Nipride)
both
neither

is the ans is 1 ?
i m not sure abt bcoz it shoud b 2.

Nazia · 04-27-2006, 08:18 PM

i think correct answer is 1.

bcoz ,nitroglycerine undergoes nonenzymatic decompostion by interaction with variety of thiols such as cysteine ,N-acetyl cysteine present in tissue to form nitrosothiol intermediate before undergoing enzymatic biotransformation to release NO.

jak073 · 04-28-2006, 04:52 PM

i think the answer is two becos the nitroprusside produces a thio metabolite (that is toxic) and then cyanide ....when on this drug we need to monitor for these toxicities...i dont know.hmmm

Nazia · 04-28-2006, 05:52 PM

what is the correct answer for the question,and can u plz tell me form which book is this Q,so that i can also prepare from it.

04-27-2006, 05:18 PM	#1 (permalink)
romi1011 Trying to make mom and pop proud Join Date: Jun 2005 Posts: 25	question Q. Requires thio- containing agents to generate nitric oxide (NO) nitroglycerin nitroprusside sodium (Nipride) both neither is the ans is 1 ? i m not sure abt bcoz it shoud b 2. Last edited by romi1011 : 04-27-2006 at 05:18 PM. Reason: Automerged post

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04-27-2006, 08:18 PM	#2 (permalink)
Nazia Within my grasp! Join Date: Jul 2005 Posts: 132	i think correct answer is 1. bcoz ,nitroglycerine undergoes nonenzymatic decompostion by interaction with variety of thiols such as cysteine ,N-acetyl cysteine present in tissue to form nitrosothiol intermediate before undergoing enzymatic biotransformation to release NO.

04-28-2006, 04:52 PM	#3 (permalink)
jak073 Within my grasp! Join Date: Jun 2005 Posts: 223	i think the answer is two becos the nitroprusside produces a thio metabolite (that is toxic) and then cyanide ....when on this drug we need to monitor for these toxicities...i dont know.hmmm

04-28-2006, 05:52 PM	#4 (permalink)
Nazia Within my grasp! Join Date: Jul 2005 Posts: 132	what is the correct answer for the question,and can u plz tell me form which book is this Q,so that i can also prepare from it.

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