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fafy
11-22-2006, 04:50 AM
Hi guys
do you know what does "nonligand" mean?! Is it a synonym for ligand?!
Thank you.
Fafy

preeti_80
11-22-2006, 03:54 PM
hi friend,
let me try this
i dont think ligand is a synonym of nonligand. it looks like antonym.

In chemistry (http://en.wikipedia.org/wiki/Chemistry), a ligand is an atom (http://en.wikipedia.org/wiki/Atom), ion (http://en.wikipedia.org/wiki/Ion), or molecule (http://en.wikipedia.org/wiki/Molecule) (see also: functional group (http://en.wikipedia.org/wiki/Functional_group)) that generally donates one or more of its electrons (http://en.wikipedia.org/wiki/Electron) through a coordinate covalent bond (http://en.wikipedia.org/wiki/Coordinate_covalent_bond) to, or shares its electrons through a covalent bond (http://en.wikipedia.org/wiki/Covalent_bond) with, one or more central atoms or ions (these ligands act as a Lewis base (http://en.wikipedia.org/wiki/Lewis_base)). Fewer examples exist where a molecule can be described as a ligand that accepts electrons from a Lewis base (hence, the ligand acts as a Lewis acid (http://en.wikipedia.org/wiki/Lewis_acid).

to make it more clear from our pharmacology point of view..
we have endogenous ligands like epinephrine, norepinephrine which bind to the receptors to exert their effect.

hope it clears
all the best
preeti

fafy
11-22-2006, 06:06 PM
Check on p.224 of CPR about the non competitive antagonist. I think there nonligand means ligand of a receptor. Even if it doesn't seem logical to me!!!