PDA

View Full Version : Urgent, need help please !



mpb
11-29-2006, 01:10 PM
Hi everyone !

is the elimination of non linear kinetics follows zero order reaction ?
and if we draw the graph of drug elimination of auc vs dose, then what is the shape for that ?

Elimination of linear kintics follows first order reaction and if we draw a graph it is bell shape. if i am wrong please correct me .


Thanks !

dussamkumar
11-29-2006, 01:14 PM
yes linear kinetics follows zero order reaction and if we draw the graph it shows straight line. and has a charecterstics of '' ph is changing parameter''.
hope this will help.
all the best boss.
kumar.

colu
11-29-2006, 04:06 PM
hi mpb,
if you ask about non linear pharmacokinetics, then it's elimination rates depend on dose.
at higher dose-zero order
at intermediate dose-min order
at low dose-first order
see the graph on page no-121, ch-6, cpr.

please ,correct me if i am wrong.

try to pass
11-29-2006, 04:45 PM
the elimination of non linear kinetics follows zero order only at very high dose..

both first and zero at intermediate dose

first order only at low dose

cherryfda
11-29-2006, 05:19 PM
the elimination of non linear kinetics follows zero order only at very high dose..

both first and zero at intermediate dose

first order only at low dose

ya that is right

lite
11-29-2006, 05:59 PM
ya that is right

dear cherry
can u give us a breife summary about the kinetics .. linear & non linear ?
& their orders & graphs ?????:blush: :blush: :blush:
thanks in advance