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exam_pharma
08-01-2008, 01:25 AM
Can someone tell me 6-mercaptopurine prodrug or not?

Thank you.

OzPharmacist
08-01-2008, 05:21 AM
Hi exam_pharma,
A far as I know 6-mercaptopurine is not a pro-drug as it is the active metabolite of azathiopine. A definition of a Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. For example, sulfasalazine (http://www.medterms.com/script/main/art.asp?articlekey=703) is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products -- 5-aminosalicylic acid (5ASA) and sulfapyridine -- before becoming active as a drug.
So azathioprine is the pro-drug not 6-mercaptopurine.
Hope this helps!

OzPharmacist
08-01-2008, 05:23 AM
Hi exam-pharma,
As far as I know 6-mercaptopurine is not a pro-drug as it is the active metabolite of azathioprine. Definition of a Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. For example, sulfasalazine is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products -- 5-aminosalicylic acid (5ASA) and sulfapyridine -- before becoming active as a drug.
So azathioprine is the pro-drug not 6-mercaptopurine.
Hope this helps! :)

OzPharmacist
08-01-2008, 05:24 AM
Sorry for posting that twice!