Hadi

That is wrong: DECREASE in K conc. equals digoxin toxicity.

Miacalcin is Not alendronate, this leaves only Actonel as the only answer.

Acid-labile are meds that are easily destroyed by acidic media of stomach, that is why most PCNs are given parentrally.

Penicillin family are acid-labile drugs that means it is easily destroyed in acidic environment, so in infants where the the pH is elevated allows for better bioavialability of these kinds of meds.

I am little confused..Oncology..antitumor antibiotics --only bleomycin is G2 and M phase specific right? Right Antimetabolites --not folic acid but purine and pyrimidines are s phase specific..Right I read something about giving procrait (epoitin alpha ) with one of the antitumor drug now i cant find it anywhere....i forgot which one...is it cyclophosphamide or ...almost evoprated Let us get that straight... antitumor drugs as it affect the tumor that divides rapidly it also affect normal human cells that divides rapidly mainly: hair cells, gastrointestinal cells and blood cells. So patients on antitumor drugs can suffer from Alopecia, peptic ulcers, and sever anemia. So my friend Procrit can be given to patients on any chemotherapy with sever anemia.

one year

Sorry Swetan for the late response but regarding: TPN : did you do calculation of BEE and from that calculation of calorie requirements and also respiratory quotinet kind of things?? electrolyte requirement (numbers for each) during nutritional support... I didnot do that...that was too much for me and i didnot get any related questions.. Just know how to calculate the amount of calories in TPN Ca and PO4 is the main incompatability...due to precipitation...usually phosphate added first to a TPN and Ca added last. know that dextrose in TPN should not exceed 25kcal/kg/d to avoid hepatic stetosis. Know the state of hypophosphatemia(the normal range we already know in renal failure chapter) it is the only one that is calculated in mmole not meq. Max dose 0.64mmol/kg and there is a max rate of 7.5mmol/h if you had any tricks to remember arrhthmetic stages mechanism (depolarization and repolarization stuff) Just try to remember the mechanism table in that chapter. and also infectious diseases : can you gimme an example how did u study that ( I am basically familier with moa and side effects names (brands not all but yes for the ones moves in pharmacy) I always get mixed with with which perticuler moa it works (special ones you know like cephelosporin cross csf and -ve and dox travell diarrhea ,tc rockey mountian fever ...but u know many of them covers staphylocoaal and influenza and pneumocacal which is confusing.. I am just wondering if u had any key to remember it Infectious disease is a big but important chapter: Regarding mechanism: Those that inhibit the protein synthesis the only ones that binds to 30S ribosomal subunit is Aminoglycosies(cidal), tetracycline(static), Tigecycline(static). No problem with PCN we all pretty much familiar with it..know the PCN+B-lactamase inhibitor combination like what is Unasyn and what is Zosyn and only Augmentin is available PO. For Cephalosporin: I knew the first generation..they are only few of them..brand and generic...know that Ancef(cefazolin) is the only one that is avilable IV..so if the patient is hospitalized and is on Ancef and we want to discharge him home we can switch him to Keflex that is same generation but PO or any other po of the same class. Second generation cephalosporin: Anyone starting with Cef-, Cefuroxime is important in that class as it is available PO and IV. Third generation:all ending in -ime or -one except cefuroxime(2-generation) and ceftibutin and cefdinir(3-generation). Know that rocephin is excreted via biliary tract and can be given even if crcl Know antibiotic that covers G(+): Vanco and cubicin is the most popular. I knew everything about Fluroquinolones..just everything in apha including tables. Macrolide is so important and used a lot: remember it needs adequate dilution and slow infusion in IV adminsteration All hepatically eleminated except Biaxin which you should never refrigerate.Also all are safe in pregnancy(category B) except Biaxin©. azithromycin available IV and PO(tab/soln/powder) Sulphonamides: know that septra or bactrim is TMP-SMX and the ratio is 1:5 this means that single strength is 80/400 and double strength is 160/800 Tetracycline: photosynsitivity, use in pregnancy and children Clindamycin: coveraaerobic G(+) including MRSA and anaerobic G(-) Primaxin, Merrem, Invanz is a B-lactam antibiotic better avoid in PCN allergy. Azactam only covers active aerobic G(-) bacilli, including pseudomonas Tygacil: covers anaerobic, G(+)including MRSA, and G(-) but NOT pseudomonas. Treatment of pseudomonas is usually a combination of Aminoglycosides and one of the following: -PCN(MPCAT) -Cephalosporin(ceftazidime, cefoperazone, cefapime) -FQ but avoid in children -Azactam Only TWO agents covers Enterococcus: -PCN...if allergy go to: -Vanco....if failed go to zyvox, synercid, or cubicin. Treatment of MRSA: vanco, zyvox, synercid, Cubicin, Tygacil. In pregnancy avoid: FQ, Tetracycline, sulphonamide, Biaxin, Tygacil, Ketek. Hepatic Elemination: Synercid, Avelox, Azithromycin, erythromycin, Minocin, septra, cleocin, Tygacil. All others are renally eleminated. ok guys that is how i studied antibiotics. Hope that would help somebody.

Amazon.com: Pharmacy & Federal Drug Law Review: A Patient Profile Approach: Books: David C Kosegarten,Douglas J Pisano

I donot mind helping at all... TPN from appleton, apha and shargel is enough. I did herbals from apha, indication and side effects is enough. Forget about that book if you are going early november, my advice is to go on the topics you read one more time and donot postpone your exam date. I donot think prenaplex is worth the $50, I would rather buy a book that i would refer to it later than this. Also i donot believe in books like pharmsuccess or any other book review of questions and answers. I think studying the main material is far better than wasting money on this kind of books and CDs. But this is only my opinion.... The very few chapters in apha, i didnot read it throughly just browsed through them. I got only one or two. I studied that big table that tells you the use of certain additives to medications like what is benzalkonium chloride use for. Study kinetics from shargel ...no big formulas..Just know: Vd=dose/plasma conc t1/2=0.693/Ke Cl=KeVd Conc at steady state= Rate/KeVd Cl=FD/AUC first order kinetics: logcp=logc-kt/2.303 Know the difference between absolute and relative bioavilability. Know how much percentage of steady state is reached after each t1/2 and know it the other way around like it takes 5 t1/2 to reach 96.9% Also know pH=pKa + log salt /acid That is all what you need to know in Kinetics Immunization is VERY important...anything related to pediatrics like ADHD,CF, and the rest of the chapter. Also the geriatric chapter..of course you know that big population here in USA is geriatrics so they care to ask a lot of related questions. Also toxicology is important...got a lot of them.

1- You should study math very well..I had a lot of math questions..it seemed to me every other question was a math. It is an advantage if you excel that part as you would be sure that you answered correctly at least 1/3 of the exam right and if you have general information inthe rest you would at least pass. I used APHA, comprhensive review, appleton. Pay attention to TPN and first order kinetics. 2-No idea what is kaptest? 3-I got patient profile book named "Pharmacy and Fedral Law Review:A Patient Profile Approch" I liked it so much...it made me get used on what to look for in patient profile...raised some points not in APHA...it is good if you have plenty of time but if not donot bother. 4-It is important to remember imprtant dosages like Metformin, Lithium, Amiodarone, Digoxin, Phenytoin these are the famous one i remember. For me i studied as much as i can as i was terrified... You should know if loading doses is needed for some drugs. Normal values for normal electrolyte...sure you need to study that. 5- Infectious disease is not tricky...just study APHA very well. Compounding: i borwsed through this section..i got may be one or two questions. 6-You should not remember the ratio in birth control pills, But you should remember the dosage forms like which one comes in patches and the frequency of application... which ones have progestin only...if you can study some names in each of monophasic, diphasic and triphasic. Know seasonale and seasonique are 84 active pills.. 7-Of course there is a lot of weightage on oncology, hiv, immunization, and transplant...i got a lot on those topics and also i was asked the brand names in the immunization section..that was hard:( I would say study brand names Donot forgot herbals...i got a lot of those. Hope that helped...Good Luck.

Orwa, Yes in my hospital there is an oncology department where there are specific pharmaist for preparing the chemotherapy. Most female pharmacist does not like to prepare those kind of stuff and of course you know why, because it is teratogenic. There are some pharmacist who are well trained to work in the IV room (that is responsible for preparing all the parentrals for the hospital including the iv insulin if that what you mean by antidiabetic drugs), or the OR which is the operation room that prepares irrigation during surgeries or preparing parentrals for delivering women something like that. Pharmnj, I guess you should contact the florida board, i really donot have any idea about your situation. It is safer to talk to them. Preeti 80, I just walked into a lot of hospitals and explained my situation to the pharmacy manager, some said no thank you and finally one said ok. So my advice is to keep trying to contact hospitals.

Actually Orwa there should be no difference between foreign pharmacist and PharmD. Foreign pharmacist is supposed to be a graduate of 5 year pharmacy school and the internship experience inside the united states that is a total of almost 6 years. Also PharmD is a graduate of a 5 years of classes in a pharmacy school and a 1 year of rotation which is something similar to internship but the places they do the internship or they name it rotation should be in places approved by the college they graduated from. They should do rotation in retail, hospitals and some states require industry. From my experience i can see that a foreign pharmacist has always some doubts around him until he proves himeself. Good luck to everybody.

I did all my internship in a hospital as a volunteer though i have the green card and donot need any sponsoring. I worked as a technician for some time before getting my certificate in a retail setting and i didnot like it at all in retail. I see that most of the internship in a retail is mostly technician work. The hospital was so good experience for me, i got a lot of experience in data entry in the inpatient pharmacy and the out patient pharmacy in the hospital is the same as retail pharmacy. I did a lot of rounding in intensive care units to see what medications patients are using what need to be stopped based on their lab values, how to adjust insulin, warfarin, heparin, and so on. That was so much fun, a lot of interaction with doctors and nurses. Some doctors explain so much that helped me a lot to have in depth understanding in a lot of things. I got a lot of training in the IV room that prepares parentrals to the hospitals like TPNs and so on. Also i was trained in the narcotic room that gives you a lot of experience on the law and regulation for the narcotics and lock up medications. For me i live in Florida and the internship hours here is so long and i didnot find place in retail to offer a good pay rate for most of the internship hours, they offered technician or slightly higher than technician rate for most of internship and really good rate in the last 500 hours. So i sacrificed what i consider very low rate since i donot need any sponsoring in order to get a good experience that is far better than the technician experience you get in a retail setting. For me i cannot stand the whole day on my feet in retail, not to mention having to deal with very rude patients. In hospitals you SIT on nice desk most of the day and your interaction is only with nurses and doctors, sometimes the nurses are grumpy but not for sure as bad as the patients. The point is that the pay rate of hospitals is a little bit lower than retail BUT the full time in the hospital is only 32 hours not 40. For me as a female that is very convenient so i can work only 4 not 5 days a week so i have some time for my kids, or you can work in the hospital as full time employee and part time in a retail to compensate for the lower rate of hospitals and that way you can mostly get the nice environment of the hospital setting. Afterall guys that is only my opinion based on my experience and my needs. Hope that helped Orwa.

I know it is hard to remember all the information but try to break it down to sections and study it hard as you cannot ignore HIV in NAPLEX, i would recommend to: -Study the class of toxicity of the 3 drug classes, then specific toxicty that is charactaristic to some medications for example know that Cirixivan cause nephrolithiasis so the patient had to drink a lot of water and so on. -Know which class need dose adjustment in hepatic and renal impairement and the exception in each class. -Know that Zidovudine is the only HIV medication that is available IV. -Know which need to be taken on empty stomach and which with food. Also know why Videx must be adminstered with a buffer (to prevent gastric acid degradtion of Videx) and this way should be separated from medication that need acidic environment for absorbtion as azoles antifungals, quinolones, tetracyclines, indinavir, retonavir and delavirdine. -Know the 4 contraindication for the use of amprenavir oral solution, and it should be avoided in sulfa allergy and it is adminstered with vit E and propylene glycol. -Know that ritonavir, kaletra caps and enfuvirtide(only one SC adminsteration) should be refrigerated. -Know therapy during pregnancy. -know post exposure prophylaxis. -Know primary prophylaxis for PCP and MAC and when it should be started and when it should be stopped. -Know how HIV diagnosed: ELISA for screening and Western blot for confirmation. -Know how HIV monitored: Viral load and CD4 cell count, know what each of them assess. *It is optional for you if after all that you feel that you can still have some space in your mind to know the prophylaxis and maintainence of the toxoplasmosis, meningitis and the rest of the big tables in the APHA, for me i only browsed through this part. *It is also optional if you can know the combination of medication in each class as combivir is zidovudine and lamuvidine. For me i studied the combination medication names in the 3 classes. Those are the broad lines to make it easier for you guys to study the HIV chapter. I hope that helped. Good Luck.

I used www.rxlist.com for top 300 drugs.

YES you should pay good attention to all the tables.

I studied the 2nd edition of APHA, but I added to it few drugs that I knew was in the new editions like for example humira, ornecia, pramilintide, byetta,daytrana...just few stuff here and there. My exam had a lot of math questions, other than that it was all over the place. I had a lot of chemo, herbals, toxicology, asthma, diabetes,cvs, antibiotics. I had few kids patient profile. I studied the top 300 drugs and i think it is more than enough. Regarding the dosage forms, I would recommend to know everything about the famous drugs in each drug class for example: digoxin, theophylline, lithium. Know all patches dosage forms, there are lot of them. Hope that helps...

Guys, I only studied APHA, nothing else. Make sure to study this book very well. I also referred to Appleton and Lange, for only the Math part in it. Good luck to all of you.

Thank you so much Mona for the good wishes. I wish you the best of luck and of course i will pray for you.

I got 138. :tup: Would like to thank everyone on this forum.. Good luck for future NAPLEX takers.

Would someone help me to figure out how to solve these two kinds of questions: -If you have Lasix with pKa of 3.7, How would you expect the ionization at physilogic pH? -How would you convert methadone dose, for example, to morphine using the equianalgesic chart?

Would someone help me to figure out how to solve these two kinds of questions: -If you have Lasix with pKa of 3.7, How would you expect the ionization at physilogic pH? -How would you convert methadone dose for example to morphine using the equianalgesic chart?

Wow congratulations...

You know what: If you recalculate it using the correct conversion that is 0.5mg=500 000ng you would get the same answer because the value of the dose cancel itself out in final formulae. I mean you multiply now by 500 000 and divide by vd value that is now bigger (314542). Now Css= 0.77x500 000/24.314542.0.003= 17 ng/ml Sorry for the mistake that might confused anybody.

Are you sure they needed the answer in ng/ml not mcg/ml? I can not think of any other way to get it right..