Ritonavir( Norvir)
Ritonavir received FDA approval in 1996 for use in adults with HIV infection. Pediatric approval followed in 1997.
Ritonavir is available in soft-gel capsules and in oral solution.
Dosing:
Adult -------------------------------- 600 mg BID
Pediatrice
1 month- 12 years------350- 400 mg BID
Ritonavir should be taken with food.
FDA Pregnancy Category B.
Ritanovir inhibits a liver enzyme that normally metabolizes away protease inhibitors, CYP3A4. The drug's molecular structure inhibits CYP3A4, so a low dose can be used to enhance any other protease inhibitors.